Stapling strategy enables improvement of antitumor activity and proteolytic stability of host-defense peptide hymenochirin-1B-Reference-Cited by-同舟云学术

Stapling strategy enables improvement of antitumor activity and proteolytic stability of host-defense peptide hymenochirin-1B

Published:2018 Issue:39 Volume:8 Page:22268-22275
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Yulei¹²³⁴⁵,Wu Minghao¹²³⁴⁵,Chang Qi¹²³⁴⁵,Zhao Xia¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs

2. Ministry of Education

3. School of Medicine and Pharmacy

4. Ocean University of China

5. Qingdao 266003

Abstract

A series of stapled peptide analogs of hymenochirin-1B were efficiently prepared by an Fmoc-SPPS procedure. The peptide stapling strategy can improve the helicity, proteolytic stability and tumor cell-killing activity of linear peptide hymenochirin-1B.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA03446J

Reference38 articles.

1. Carbohydrate-based vaccines for oncotherapy

2. Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development

3. The hymenochirins: A family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae)

4. An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties

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