Catalytic, selective, and stereocontrolled construction of C4 quaternary and homobenzylic dihydroisoquinolones by sp3 C

Catalytic, selective, and stereocontrolled construction of C4 quaternary and homobenzylic dihydroisoquinolones by sp3 C–H benzylation

Published:2020 Issue:15 Volume:10 Page:8805-8809
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Beng Timothy K.¹²³⁴^ORCID,Moreno Antonio¹²³⁴

Affiliation:

1. Department of Chemistry

2. Central Washington University

3. Ellensburg

4. USA

Abstract

A diastereoselective and catalytic C(sp³)–C(sp³) coupling protocol wherein β-amino sp³ C–H bonds are replaced by sp³ C–benzyl bonds, leading to C4 quaternary and homobenzylic dihydroisoquinolones, is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA10888B

Reference39 articles.

1. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics

2. Privileged scaffolds for library design and drug discovery

3. Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

4. Opportunity Knocks: Organic Chemistry for Fragment-Based Drug Discovery (FBDD)

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