Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters-Reference-Cited by-同舟云学术

Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters

Published:2022 Issue:27 Volume:12 Page:17617-17620
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Beng Timothy K.¹^ORCID,Rodriguez Morgan J.¹,Borg Claire¹

Affiliation:

1. Department of Chemistry, Central Washington University, Ellensburg, WA 98926, USA

Abstract

The catalytic halolactonization of readily affordable γ-lactam-tethered alkenoic acids has facilitated the site-selective, efficient, and stereocontrolled synthesis of halogenated fused γ-lactam-δ-lactones.

Funder

Central Washington University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA02167F

Reference61 articles.

1. The future of the β-lactams

2. Biologically active γ-lactams: synthesis and natural sources

3. The first solvent-free synthesis of privileged γ- and δ-lactams via the Castagnoli–Cushman reaction

4. Biologic Activity of ε-Caprolactam

5. 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

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