Synthesis and characterization of the first inhibitor ofN-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)-Reference-Cited by-同舟云学术

Synthesis and characterization of the first inhibitor ofN-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

Published:2017 Issue:95 Volume:53 Page:12814-12817
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Castellani Beatrice¹²³⁴^ORCID,Diamanti Eleonora¹²³⁴^ORCID,Pizzirani Daniela¹²³⁴^ORCID,Tardia Piero¹²³⁴^ORCID,Maccesi Martina⁵⁶⁷⁴^ORCID,Realini Natalia¹²³⁴^ORCID,Magotti Paola¹²³⁴^ORCID,Garau Gianpiero¹²³⁴^ORCID,Bakkum Thomas¹²³⁴^ORCID,Rivara Silvia⁸⁹¹⁰⁴^ORCID,Mor Marco⁸⁹¹⁰⁴^ORCID,Piomelli Daniele¹¹¹²¹³¹⁴^ORCID

Affiliation:

1. Drug Discovery and Development

2. Istituto Italiano di Tecnologia

3. 16163 Genoa

4. Italy

5. Department of Chemistry and Pharmaceutical Sciences

6. University of Ferrara

7. 44121 Ferrara

8. Food and Drug Department

9. University of Parma

10. 43124 Parma

11. Departments of Anatomy and Neurobiology

12. Biochemistry and Pharmacology University of California

13. Irvine

14. USA

Abstract

ARN19874 is a quinazolinedione sulfonamide derivative that inhibits NAPE-PLD, a membrane-associated enzyme that cleavesN-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs).

Funder

Foundation for the National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC07582K

Reference22 articles.

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4. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: A novel enzyme of the β-lactamase fold family releasing anandamide and other N-acylethanolamines

5. H. B. Brooks , S.Geeganage , S. D.Kahl , C.Montrose , S.Sittampalam , M. C.Smith and J. R.Weidner , in Assay Guidance Manual , Bethesda (MD) , 2004

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