New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAF<sup>V600E</sup>/VEGFR-2 inhibition, and computational studies-Reference-Cited by-同舟云学术

New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAF^V600E/VEGFR-2 inhibition, and computational studies

Published:2024 Issue:9 Volume:14 Page:5907-5925
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sabt Ahmed¹^ORCID,Khedr Mohammed A.²³^ORCID,Eldehna Wagdy M.⁴^ORCID,Elshamy Abdelsamed I.¹^ORCID,Abdelhameed Mohamed F.⁵^ORCID,Allam Rasha M.⁵^ORCID,Batran Rasha Z.¹^ORCID

Affiliation:

1. Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt

2. Department of Pharmaceutical Chemistry, College of Pharmacy, Kuwait University, Safat 13110, Kuwait

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, 11795, Egypt

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt

5. Pharmacology Department, Medical and Clinical Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt

Abstract

New pyrazolylindolin-2-one linked coumarin derivatives were designed as dual BRAFV600E/VEGFR-2 inhibitors targeting melanoma cells A375. Docking simulation showed various interactions with the binding residues in BRAFV600E and VEGFR-2 active sites.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00157E

Reference68 articles.

1. Melanoma Arising in African-, Asian-, Latino- and Native-American Populations

2. Epidemiology of skin cancer in the mature patient

3. The mitogen-activated protein kinase pathway in melanoma part I – Activation and primary resistance mechanisms to BRAF inhibition

4. Raf kinases in cancer–roles and therapeutic opportunities

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