Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-<i>Mycobacterium tuberculosis</i> agents targeting enoyl acyl carrier protein reductase (InhA)-Reference-Cited by-同舟云学术

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Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA)

Published:2024 Issue:30 Volume:14 Page:21763-21777
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Batran Rasha Z.¹^ORCID,Sabt Ahmed¹^ORCID,Dziadek Jarosław²,Kassem Asmaa F.³

Affiliation:

1. Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt

2. Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland

3. Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt

Abstract

New series of coumarin derivatives were synthesized as antitubercular agents targeting InhA enzyme with strong binding affinity within the active binding site.

Funder

Narodowe Centrum Nauki

Ministerstwo Edukacji i Nauki

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02746A

Reference60 articles.

1. Global Tuberculosis Report 2020 – Reflections on the Global TB burden, treatment and prevention efforts

2. Tuberculosis

3. Tuberculosis

4. WHO , Global tuberculosis report , 2022 , https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022

5. Multidrug-resistant Tuberculosis

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