Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers-Reference-Cited by-同舟云学术

Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers

Published:2022 Issue:43 Volume:14 Page:16270-16285
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Prajapati Kailash Prasad¹^ORCID,Anand Bibin Gnanadhason¹^ORCID,Ansari Masihuzzaman¹,Tiku Ashu Bhan¹,Kar Karunakar¹^ORCID

Affiliation:

1. Biophysical and Biomaterials Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India

Abstract

The essential amino acid tryptophan, under physiological conditions, self-assembles into amyloid-mimicking neurotoxic nanostructures, capable of driving amyloid cross-seeding of diverse proteins.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR03544H

Reference72 articles.

1. Endogenous kynurenines as targets for drug discovery and development

2. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

3. Promotion of oxidative stress by l-tryptophan in cerebral cortex of rats

4. Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

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