Self-assembling morphology-tunable single-component supramolecular antibiotics for enhanced antibacterial manipulation

Author:

Song Xin12345,Deng Xudong67385,Wang Qinghua910111213,Tian Jinjin12345,He Feng-Li67385,Hu Hai-Yu910111213ORCID,Tian Wei12345ORCID

Affiliation:

1. MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Macromolecular Science and Technology

2. School of Science

3. Northwestern Polytechnical University

4. Xi'an

5. P. R. China

6. Key Laboratory for Space Bioscience and Biotechnology

7. School of Life Sciences

8. Xi'an 710072

9. State Key Laboratory of Bioactive Substances and Function of Natural Medicine

10. and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation

11. Institute of Materia Medica

12. Peking Union Medical College and Chinese Academy of Medical Sciences

13. Beijing 100050

Abstract

This single-component supramolecular antibiotic can undergo reversible self-assembling morphology transitions under sequential ultrasonic and redox stimuli. The self-assemblies with different morphologies display effective antibacterial regulation.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanxi Province

Fundamental Research Funds for the Central Universities

Chinese Academy of Meteorological Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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