Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches-Reference-Cited by-同舟云学术

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Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

Published:2015 Issue:7 Volume:6 Page:1285-1292
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Pippione Agnese C.¹²³⁴^ORCID,Dosio Franco¹²³⁴,Ducime Alex¹²³⁴,Federico Antonella¹²³⁴,Martina Katia¹²³⁴,Sainas Stefano¹²³⁴,Frølund Bente⁵⁶⁷⁸⁹,Gooyit Major¹⁰¹¹¹²¹³¹⁴,Janda Kim D.¹⁰¹¹¹²¹³¹⁴,Boschi Donatella¹²³⁴,Lolli Marco L.¹²³⁴

Affiliation:

1. Department of Science and Drug Technology

2. University of Torino (UniTO)

3. 10125 Torino

4. Italy

5. Department of Drug Design and Pharmacology

6. Faculty of Health and Medical Sciences

7. University of Copenhagen

8. Universitetsparken 2

9. DK-2100 Copenhagen

10. Departments of Chemistry and Immunology and Microbial Science

11. The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine

12. The Scripps Research Institute

13. La Jolla

14. USA

Abstract

The hydroxytriazole system is here analysed and used to modulate acidic moieties present in lead compounds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00182J

Reference23 articles.

1. Bioisosteres and Scaffold Hopping in Medicinal Chemistry

2. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

3. Studies on New Acidic Azoles as Glucose-Lowering Agents in Obese, Diabetic db/db Mice

4. Glutamate receptor function in learning and memory

5. Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting

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2. Stereochemical and Computational NMR Survey of 1,2,3-Triazoles: in Search of the Original Tauto-Conformers;The Journal of Physical Chemistry A;2024-03-21

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4. Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans;European Journal of Mass Spectrometry;2023-11-17

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