Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD-Reference-Cited by-同舟云学术

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD

Published:2021 Issue:9 Volume:12 Page:3898-3918
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Jingda¹²³⁴^ORCID,Wang Tianqi⁵²³⁴,Liu Panpan⁶⁷⁸⁹⁴,Yang Fuyuan¹⁰²³⁴,Wang Xudong¹¹¹²¹³⁴^ORCID,Zheng Weilong¹⁴¹⁵¹⁶⁴,Sun Wenlong⁶⁷⁸⁹⁴^ORCID

Affiliation:

1. College of Life Science

2. Yangtze University

3. Jingzhou

4. China

5. College of Agriculture

6. Institute of Biomedical Research

7. School of Life Sciences

8. Shandong University of Technology

9. Zibo

10. Health Science Center

11. College of Pharmaceutical Science

12. Zhejiang University of Technology

13. Hangzhou

14. Institute of Biomass Resources

15. Taizhou University

16. Taizhou

Abstract

Hesperetin as a major bioflavonoid in citrus fruits improves NAFLD by suppressing hepatic oxidative stress and inflammation.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Natural Science Foundation of Shandong Province

Science and Technology Program of Hubei Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO02736G

Reference62 articles.

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2. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation

3. Gastrointestinal complications of obesity: Non-alcoholic fatty liver disease (NAFLD) and its sequelae

4. Nonalcoholic Steatohepatitis

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