Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators-Reference-Cited by-同舟云学术

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Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators

Published:2015 Issue:5 Volume:7 Page:867-876
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Workman David G.¹²³⁴,Tsatsanis Andrew⁵⁶⁷⁸,Lewis Frank W.¹²³⁴,Boyle John P.⁹¹⁰⁷⁸,Mousadoust Maryam¹²³⁴,Hettiarachchi Nishani T.⁹¹⁰⁷⁸,Hunter Michael¹²³⁴,Peers Chris S.⁹¹⁰⁷⁸,Tétard David¹²³⁴,Duce James A.⁵⁶⁷⁸¹¹

Affiliation:

1. Department of Applied Sciences

2. Faculty of Health and Life Sciences

3. Northumbria University

4. Tyne and Wear NE1 8ST, UK

5. School of Biomedical Sciences

6. The Faculty of Biological Sciences

7. University of Leeds

8. Leeds, UK

9. LICAMM

10. Faculty of Medicine and Health

11. Oxidation Biology Unit

Abstract

We report that novel 1-hydroxypyridin-2-ones show comparable neuroprotective results to deferiprone in a cell culture model of Parkinson's disease.

Funder

European Research Council

Healthcare Infection Society

Parkinson's UK

Alzheimer's Research Trust

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C4MT00326H

Reference56 articles.

1. Brain iron pathways and their relevance to Parkinson's disease

2. ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA

3. 6-Hydroxydopamine promotes iron traffic in primary cultured astrocytes

4. Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease

5. Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson’s disease

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