Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1<i>H</i>)-one iron chelators in an <i>in vitro</i> cell model of Parkinson's disease-Reference-Cited by-同舟云学术

Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease

Published:2022 Issue:9 Volume:51 Page:3590-3603
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Lewis Frank W.¹^ORCID,Bird Kathleen¹,Navarro Jean-Philippe¹,El Fallah Rawa²,Brandel Jeremy²,Hubscher-Bruder Véronique²^ORCID,Tsatsanis Andrew³⁴,Duce James A.³⁴,Tétard David¹^ORCID,Bourne Samuel⁵,Maina Mahmoud⁵,Pienaar Ilse S.⁵⁶^ORCID

Affiliation:

1. Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, UK

2. Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France

3. School of Biomedical Sciences, The Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK

4. Alzheimer's Research UK Cambridge Drug Discovery Institute, Cambridge Bio-medical Campus, University of Cambridge, Cambridge, UK

5. School of Life Sciences, University of Sussex, Falmer, Sussex BN1 9PH, UK

6. Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Abstract

We report that novel 1-hydroxypyazin-2(1H)-ones show comparable neuroprotective effects to related iron chelators in a cell culture model of Parkinson's disease, despite significant differences in their physicochemical properties.

Funder

Royal Society of Chemistry

Royal Society

FP7 Ideas: European Research Council

Alzheimer's Society

Northumbria University

Parkinson's UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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