Synthesis of amantadine clubbed <i>N</i>-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies-Reference-Cited by-同舟云学术

Synthesis of amantadine clubbed N-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies

Published:2023 Issue:36 Volume:13 Page:24988-25001
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zahra Fatima Tuz¹,Saeed Aamer¹^ORCID,Ahmed Atteeque¹,Ismail Hammad²,Ijaz Muhammad Umar³,Albericio Fernando⁴⁵^ORCID

Affiliation:

1. Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan

2. Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat, 50700, Pakistan

3. Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad 38040, Pakistan

4. Peptides Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa

5. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain

Abstract

A series of ten novel compounds were synthesized by incorporating a 1,3 thiazole core into amantadine and their structures were validated using different analytical and spectral methods such as FTIR, EI-MS, 1H NMR, and 13C NMR.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA05330J

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