Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors

Published:2022 Issue:1 Volume:12 Page:561-577
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Othman Ismail M. M.¹,Alamshany Zahra M.²,Tashkandi Nada Y.²,Gad-Elkareem Mohamed A. M.¹,Abd El-Karim Somaia S.³^ORCID,Nossier Eman S.⁴

Affiliation:

1. Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt

2. Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 42805, Jeddah 21551, Saudi Arabia

3. Department of Therapeutic Chemistry, National Research Centre, Dokki, Cairo 12622, Egypt

4. Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt

Abstract

Deregulation of various protein kinases is considered as one of the important factors resulting in cancer development and metastasis, thus multi-targeting the kinase family is one of the most important strategies in current cancer therapy.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA08055E

Reference76 articles.

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