Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii-Reference-Cited by-同舟云学术

Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii

Published:2021 Issue:43 Volume:19 Page:9506-9513
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Roux Indra¹^ORCID,Bowles Simon²^ORCID,Kalaitzis John A.²³^ORCID,Vuong Daniel²^ORCID,Lacey Ernest²³^ORCID,Chooi Yit-Heng¹^ORCID,Piggott Andrew M.³^ORCID

Affiliation:

1. School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia

2. Microbial Screening Technologies Pty. Ltd, Smithfield, NSW 2164, Australia

3. Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia

Abstract

Burnettiene A is a novel cytotoxic tridecaketide decalin polyketide from Aspergillus burnettii. Its biosynthesis was elucidated by heterologous expression in fungi.

Funder

Cooperative Research Centres, Australian Government Department of Industry

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01766G

Reference42 articles.

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2. Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway