Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)

Published:2019 Issue:6 Volume:10 Page:840-866
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Romsdahl Jillian¹²³⁴⁵^ORCID,Wang Clay C. C.¹²³⁴⁵

Affiliation:

1. Department of Pharmacology and Pharmaceutical Sciences

2. School of Pharmacy

3. University of Southern California

4. 1985 Zonal Avenue

5. Los Angeles

Abstract

This review covers advances made in genome mining SMs produced by Aspergillus nidulans, Aspergillus fumigatus, Aspergillus niger, and Aspergillus terreus in the past six years (2012–2018). Genetic identification and molecular characterization of SM biosynthetic gene clusters, along with proposed biosynthetic pathways, is discussed in depth.

Funder

U.S. Department of Defense

National Institute of Allergy and Infectious Diseases

National Aeronautics and Space Administration

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00054B

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