Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer's agents
Author:
Affiliation:
1. Centro de Química Estrutural
2. Instituto Superior Técnico
3. Universidade de Lisboa
4. 1049-001 Lisboa
5. Portugal
6. Centre for Nano and Material Sciences
7. Jain University
8. Jain Global Campus
9. Bangalore 562112
10. India
Abstract
Donepezil and tacrine hybrids, containing a 2-hydroxyphenyl-benzimidazole chelating moiety and with multifunctional anti-AD activity, are evaluated in terms of metal (Cu and Zn) chelating capacity.
Funder
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ00117K
Reference50 articles.
1. Alzheimer's Disease
2. Drug Development Based on the Metals Hypothesis of Alzheimer's Disease
3. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
4. Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
5. New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties
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