Selective monoalkylation of amines with light electrophiles using a flow microreactor system-Reference-Cited by-同舟云学术

Selective monoalkylation of amines with light electrophiles using a flow microreactor system

Published:2015 Issue:4 Volume:2 Page:324-327
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Lebleu Thomas¹²³⁴⁵,Maddaluno Jacques¹²³⁴⁵,Legros Julien¹²³⁴⁵

Affiliation:

1. Normandie Univ

2. COBRA UMR 6014

3. Univ Rouen

4. INSA Rouen and CNRS

5. 76821 Mont-Saint-Aignan

Abstract

The challenging direct monoalkylation of primary and secondary amines with small triflates (C₁ to C₃) was accomplished in a flow microreactor by virtue of efficient mixing and short reaction times.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/QO/C4QO00342J

Reference31 articles.

1. The Selectivity of Chemical Reactions Disguised by Diffusion. Part I: Chemical Selectivity Disguised by Mixing

2. Disguised chemical selectivities

3. Synthesis of secondary amines

4. Cesium Hydroxide Promoted Chemoselective N-Alkylation for the Generally Efficient Synthesis of Secondary Amines

5. CsOH-promoted chemoselective mono-N-alkylation of diamines and polyamines

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Guide for Mono‐Selective N‐Methylation, N‐Ethylation, and N‐n‐Propylation of Primary Amines, Amides, and Sulfonamides and Their Applicability in Late‐Stage Modification;Chemistry – A European Journal;2024-03-05

2. Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed bed vs. aqueous solution;Green Chemistry;2021

3. Methyl transfer in quaternary alkylammonium salts, derivatives of 1,4:3,6-dianhydrohexitols;Journal of Molecular Structure;2020-04

4. Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry;Organic & Biomolecular Chemistry;2020

5. The selective n-alkylation of monoethanolamine in PTC condition;MOJ Bioorganic & Organic Chemistry;2018-01-31