Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry-Reference-Cited by-同舟云学术

Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry

Published:2020 Issue:18 Volume:18 Page:3481-3486
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Manneveau Maxime¹²³⁴⁵,Tanii Saori⁶⁷⁸⁹¹⁰,Gens Fanny¹²³⁴⁵,Legros Julien¹²³⁴⁵^ORCID,Chataigner Isabelle¹²³⁴⁵^ORCID

Affiliation:

1. Normandie Université

2. UNIROUEN

3. CNRS

4. INSA Rouen

5. COBRA laboratory

6. Department of Organic Chemistry

7. Graduate School of Pharmaceutical Sciences

8. Tohoku University

9. Aoba

10. Japan

Abstract

(3 + 2) Dearomatizing cycloaddition of 3-cyanoindoles occurs in smooth conditions with a non-stabilized azomethine ylide, to yield tricyclic indolines in only 1 min under microflow conditions using 3 equiv of the dipole precursor vs. 6 equiv. in a batch reactor.

Funder

Tohoku University Center for Gender Equality Promotion

Université de Rouen

Centre National de la Recherche Scientifique

Institut National des Sciences Appliquées Rouen

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00582G

Reference68 articles.