A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells
Author:
Affiliation:
1. Department of Chemistry
2. University of California
3. Berkeley
4. USA
5. MRC Laboratory of Molecular Biology
6. University of Cambridge
7. Cambridge CB2 0QH
8. UK
9. Department of Medicine
10. Department of Molecular and Cell Biology
Abstract
We present the first ratiometric fluorescent probes for formaldehyde, a major reactive species in biology, operating in the visible region.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00748E
Reference51 articles.
1. R. G. Liteplo , R.Beauchamp, M. E.Meek and R.Chénier, in Formaldehyde (Concise International Chemical Assessment Documents), World Health Organization, Geneva, 2002
2. A review of human carcinogens—Part F: Chemical agents and related occupations
3. Accumulated hippocampal formaldehyde induces age-dependent memory decline
4. J. Miao and R.He, Chronic Formaldehyde-Mediated Impairments and Age-Related Dementia, InTech, Shanghai, 2012
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