Identification of 11β-HSD1 inhibitors through enhanced sampling methods-Reference-Cited by-同舟云学术

Identification of 11β-HSD1 inhibitors through enhanced sampling methods

Published:2022 Issue:32 Volume:58 Page:5005-5008
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Singh Rahul¹²³,Bhardwaj Vijay Kumar¹²³,Das Pralay²³⁴^ORCID,Purohit Rituraj¹²³^ORCID

Affiliation:

1. Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India

2. Biotechnology division, CSIR-IHBT, Palampur, HP, 176061, India

3. Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India

4. Natural Product Chemistry and Process Development, CSIR-IHBT, Palampur, HP, 176061, India

Abstract

Aminoarylbenzosuberene (AAB) molecules were chosen for in silico analysis to develop effective and more competent 11β-hydroxysteroid dehydrogenase (11β-HSD1) protein inhibitors.

Funder

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC06894F

Reference15 articles.

1. Trends in the Incidence of Type 2 Diabetes Mellitus From the 1970s to the 1990s

2. Conformational Flexibility in Crystal Structures of Human 11β-Hydroxysteroid Dehydrogenase Type I Provide Insights into Glucocorticoid Interconversion and Enzyme Regulation

3. Homology modeling and structural analysis of 11β-hydroxysteroid dehydrogenase type 2

4. Minireview: 11β-Hydroxysteroid Dehydrogenase Type 1— A Tissue-Specific Amplifier of Glucocorticoid Action1

5. 11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response

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