Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies-Reference-Cited by-同舟云学术

Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies

Published:2021 Issue:4 Volume:2 Page:1004-1020
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Lundahl Mimmi L. E.¹²³⁴⁵,Fogli Silvia⁶⁷⁸⁹¹⁰,Colavita Paula E.¹¹³⁴⁵^ORCID,Scanlan Eoin M.¹¹³⁴⁵^ORCID

Affiliation:

1. School of Biochemistry and Immunology

2. Trinity Biomedical Sciences Institute

3. Trinity College Dublin

4. Dublin 2

5. Ireland

6. Glycome Biopharma

7. Unit 4, Joyce House

8. Barrack Square

9. Ballincollig

10. Co Cork

11. School of Chemistry and Trinity Biomedical Sciences Institute

Abstract

Protein aggregation of biotherapeutics increases their immunogenicity, leading to immune-mediated adverse effects. In this review we discuss immune activation pathways, causes of aggregation and mitigation strategies.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00067E

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4. How We Treat Autoimmune Small Fiber Polyneuropathy with Immunoglobulin Therapy

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