Reply to the ‘Comment on “Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging”’ by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D

Author:

Guérard François1ORCID,Lee Yong-Sok2ORCID,Tripier Raphaël3ORCID,Szajek Lawrence P.4,Deschamps Jeffrey R.5,Brechbiel Martin W.6ORCID

Affiliation:

1. Université de Nantes, CNRS, Inserm, CRCINA, F-44000 Nantes, France

2. Center for Molecular Modeling, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA

3. Univ. Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor Le Gorgeu, 29200, Brest, France

4. Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA

5. Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC, 20375, USA

6. Center for Cancer Research, National Cancer Institute, Building 10, Room B3B69, Bethesda, MD 20892, USA

Abstract

The relevance of simplified models used for potentiometric data interpretation is discussed in the context of radiolabelling chemistry (herein the complexation of a radiometal, 89Zr, by a ligand L).

Funder

National Cancer Institute

U.S. Naval Research Laboratory

Center for Information Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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