Autofluorescent antimalarials by hybridization of artemisinin and coumarin: <i>in vitro</i>/<i>in vivo</i> studies and live-cell imaging-Reference-Cited by-同舟云学术

Autofluorescent antimalarials by hybridization of artemisinin and coumarin: in vitro/in vivo studies and live-cell imaging

Published:2023 Issue:45 Volume:14 Page:12941-12952
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Herrmann Lars¹,Leidenberger Maria²,Sacramento de Morais Adrielle³^ORCID,Mai Christina¹,Çapci Aysun¹,da Cruz Borges Silva Mariana³^ORCID,Plass Fabian⁴⁵,Kahnt Axel⁴⁵^ORCID,Moreira Diogo R. M.³^ORCID,Kappes Barbara²^ORCID,Tsogoeva Svetlana B.¹^ORCID

Affiliation:

1. Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91054 Erlangen, Germany

2. Institute of Medical Biotechnology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordon-Straße 3, 91052 Erlangen, Germany

3. Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil

4. Leibniz Institute of Surface Engineering (IOM), Permoserstrasse 15, 04318 Leipzig, Germany

5. Physical Chemistry Chair I, Friedrich-Alexander-Universität Erlangen-Nürnberg, Egerlandstrasse 3, 91058 Erlangen, Germany

Abstract

First antimalarial autofluorescent artemisinin–coumarin hybrids are highly in vitro/in vivo active, able to overcome drug resistances and are suitable for investigating their mode of action in living P. falciparum parasites by fluorescence microscopy.

Funder

Deutsche Forschungsgemeinschaft

Volkswagen Foundation

Fundação de Amparo à Pesquisa do Estado da Bahia

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03661H

Reference73 articles.