Speeding up sustainable solution-phase peptide synthesis using T3P® as a green coupling reagent: methods and challenges-Reference-Cited by-同舟云学术

Speeding up sustainable solution-phase peptide synthesis using T3P® as a green coupling reagent: methods and challenges

Published:2023 Issue:7 Volume:25 Page:2563-2571
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Mattellone Alexia¹^ORCID,Corbisiero Dario¹^ORCID,Ferrazzano Lucia¹^ORCID,Cantelmi Paolo¹^ORCID,Martelli Giulia¹^ORCID,Palladino Chiara¹,Tolomelli Alessandra¹^ORCID,Cabri Walter¹^ORCID

Affiliation:

1. P4i Lab, Department of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy

Abstract

A fast and greensolution-phase peptide synthesis (GSolPPS) via continuous protocol, addressed with propylphosphonic anhydride T3P® as coupling reagent and N-benzyloxycarbonyl-protecting group easily removed by hydrogenation is herein reported.

Funder

Fondazione del Monte di Bologna e Ravenna

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC00431G

Reference60 articles.

1. Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives

2. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes