Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones-Reference-Cited by-同舟云学术

Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones

Published:2021 Issue:40 Volume:19 Page:8754-8760
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Popovics-Tóth Nóra¹,Rávai Bettina¹,Tajti Ádám¹,Varga Bence¹^ORCID,Bagi Péter¹^ORCID,Perdih Franc²^ORCID,Szabó Pál Tamás³^ORCID,Hackler László⁴,Puskás László G.⁴,Bálint Erika¹^ORCID

Affiliation:

1. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budafoki út 8, 1111 Budapest, Hungary

2. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia

3. MS Metabolomics Research Group, Centre for Structural Study, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar tudósok krt. 2, 1117 Budapest, Hungary

4. Avidin Ltd Alsó kikötő sor 11/D, 6726 Szeged, Hungary

Abstract

A new approach for the synthesis of phosphinoyl-functionalized isoindolinones was developed. One product was utilized as a P-ligand in the synthesis of a platinum complex, and two derivatives showed promising activity against Gram positive bacteria.

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Servier

Magyar Tudományos Akadémia

Emberi Eroforrások Minisztériuma

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01610E

Reference31 articles.