Zinc oxide-NP catalyzed direct indolation of in situ generated bioactive tryptanthrin-Reference-Cited by-同舟云学术

Zinc oxide-NP catalyzed direct indolation of in situ generated bioactive tryptanthrin

Published:2018 Issue:4 Volume:20 Page:822-826
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Rai Byanju¹²³⁴,Shukla Ratnakar Dutt¹²³⁴,Kumar Atul¹²³⁴⁵^ORCID

Affiliation:

1. Medicinal & Process Chemistry Division

2. CSIR-Central Drug Research Institute

3. Lucknow 226031

4. India

5. Academy of Scientific and Innovative Research

Abstract

A ZnO-NP catalyzed direct indolation of in situ generated tryptanthrin via C–H functionalization and C–C bond formation has been developed. This novel and greener approach has been effectively utilized to accomplish the synthesis of 6-hydroxy-6-(1H-indol-3-yl)indolo[2,1-b] quinazolin-12(6H)-one derivatives in good to excellent yields with high product selectivity.

Funder

Council for Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/GC/C7GC03479B

Reference28 articles.

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2. Natural Products as Sources of New Drugs from 1981 to 2014

3. Isolation, Structure Elucidation, and Synthesis of Cytotoxic Tryptanthrin Analogues from Phaius mishmensis