A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow-Reference-Cited by-同舟云学术

A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow

Published:2022 Issue:20 Volume:12 Page:6231-6238
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Benítez-Mateos Ana I.¹^ORCID,Klein Calvin¹^ORCID,Roura Padrosa David¹^ORCID,Paradisi Francesca¹^ORCID

Affiliation:

1. Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland

Abstract

A novel thymidine phosphorylase from H. elongata has been characterized, immobilized, and applied in a flow reactor. With this biocatalyst, four halogenated nucleoside analogues with anticancer and antiviral properties were produced in high yields.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

University of Bern

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CY/D2CY00751G

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