Efficient construction of biologically important functionalized polycyclic spiro-fused carbocyclicoxindoles via an asymmetric organocatalytic quadruple-cascade reaction-Reference-Cited by-同舟云学术

Efficient construction of biologically important functionalized polycyclic spiro-fused carbocyclicoxindoles via an asymmetric organocatalytic quadruple-cascade reaction

Published:2017 Issue:4 Volume:7 Page:1863-1868
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ren Wen¹²³⁴⁵,Wang Xiao-Yan⁶³⁷⁸,Li Jing-Jing¹²³⁴⁵,Tian Mao¹²³⁴⁵,Liu Jie¹²³⁴⁵,Ouyang Liang¹²³⁴⁵,Wang Jin-Hui⁹¹⁰¹¹⁸

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center

2. West China Hospital

3. Sichuan University

4. Collaborative Innovation Center for Biotherapy

5. Chengdu 610041

6. Analytical & Testing Center

7. Chengdu 610064

8. China

9. College of Pharmacy

10. Xinjiang Medical University

11. Urumqi 830011

Abstract

A cascade organocatalysis has been developed for the asymmetric synthesis of a highly functionalized polycyclic spiro-fused carbocyclicoxindoles containing five contiguous stereogenic centers with good diastereoselectivity and high enantioselectivity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA24910H

Reference55 articles.

1. Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

2. Antimycobacterial activity of spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrids obtained by a three-component regio- and stereoselective 1,3-dipolar cycloaddition

3. Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of theMycobacterium tuberculosisProtein Tyrosine Phosphatase B

4. Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring

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