Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen-Reference-Cited by-同舟云学术

Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen

Published:2023 Issue:12 Volume:14 Page:2583-2592
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Uchiyama Hiromasa¹^ORCID,Ban Kazuho²,Nozaki Shiho²,Ikeda Yui¹,Ishimoto Takayoshi³^ORCID,Fujioka Hiroyoshi⁴^ORCID,Kamiya Mako⁴⁵,Amari Ryugo²,Tsujino Hirofumi²,Arai Masayoshi²,Yamazoe Sachi⁶,Maekawa Keiko⁶^ORCID,Kato Takuma¹^ORCID,Doi Mitsunobu¹,Kadota Kazunori¹^ORCID,Tozuka Yuichi¹,Tomita Naohito⁷,Sajiki Hironao⁷^ORCID,Akai Shuji²^ORCID,Sawama Yoshinari²⁸^ORCID

Affiliation:

1. Department of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

2. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan

3. Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8527, Japan

4. Department of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8501, Japan

5. Living Systems Materialogy (LiSM) Research Group, International Research Frontiers Initiative (IRFI), Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8501, Japan

6. Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, 97-1 Minamihokodate Koudo, Kyotanabe, Kyoto 610-0395, Japan

7. Gifu Pharmaceutical University, 1-25-4-Daigaku-nishi, Gifu 501-1196, Japan

8. Deuterium Science Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

Abstract

Expanded drug modality by H/D replacement.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00357D

Reference38 articles.

1. Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

2. Applications of Deuterium in Medicinal Chemistry

3. Deuterated Drugs and Biomarkers in the COVID-19 Pandemic

4. Deuterium in drug discovery: progress, opportunities and challenges

5. Deuterated Drugs