Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1-Reference-Cited by-同舟云学术

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Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1

Published:2013 Issue:1 Volume:4 Page:151-158
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Plowright Alleyn T.¹²³⁴,Barton Peter¹²⁵⁶,Bennett Stuart¹²⁵⁶,Birch Alan M.¹²⁵⁶,Birtles Susan¹²⁵⁶,Buckett Linda K.¹²⁵⁶,Butlin Roger J.¹²⁵⁶,Davies Robert D. M.¹²⁵⁶,Ertan Anne⁷²⁸⁴,Gutierrez Pablo Morentin¹²⁵⁶,Kemmitt Paul D.¹²⁵⁶,Leach Andrew G.¹²⁵⁶,Svensson Per H.⁷²⁸⁴⁹,Turnbull Andrew V.¹²⁵⁶,Waring Michael J.¹²⁵⁶

Affiliation:

1. Cardiovascular and Gastrointestinal Innovative Medicines Unit

2. AstraZeneca R&D

3. Mölndal

4. Sweden

5. Cheshire

6. UK

7. Medicines Evaluation

8. 151 85 Södertälje

9. Department of Applied Physical Chemistry

Abstract

Design and synthesis of a novel series of cyclohexyloxy-pyridyl inhibitors of diacylglycerol acyl transferase 1.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2013/MD/C2MD20187A

Reference22 articles.

1. Diacylglycerol acyltransferases: Potential roles as pharmacological targets

2. Antisense and small-molecule modulation of diacylglycerol acyltransferase

3. Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity

4. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor

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1. Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD 7687 on plasma triacylglycerol;Pharmacology Research & Perspectives;2019-03-09

2. Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design;Journal of Medicinal Chemistry;2016-02-26

3. Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety;ACS Medicinal Chemistry Letters;2014-09-11

4. Therapeutic Strategies for Metabolic Diseases: Small-Molecule Diacylglycerol Acyltransferase (DGAT) Inhibitors;ChemMedChem;2014-06-20

5. Discovery of 6-Phenylpyrimido[4,5-b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents;Journal of Medicinal Chemistry;2014-04-08

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