Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

Published:2014-09-11 Issue:10 Volume:5 Page:1082-1087
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

He Shuwen¹,Hong Qingmei¹,Lai Zhong¹,Yang David X.¹,Ting Pauline C.¹,Kuethe Jeffrey T.¹,Cernak Timothy A.¹,Dykstra Kevin D.¹,Sperbeck Donald M.¹,Wu Zhicai¹,Yu Yang¹,Yang Ginger X.¹,Jian Tianying¹,Liu Jian¹,Guiadeen Deodial¹,Krikorian Arto D.¹,Sonatore Lisa M.¹,Wiltsie Judyann¹,Liu Jinqi¹,Gorski Judith N.¹,Chung Christine C.¹,Gibson Jack T.¹,Lisnock JeanMarie¹,Xiao Jianying¹,Wolff Michael¹,Tong Sharon X.¹,Madeira Maria¹,Karanam Bindhu V.¹,Shen Dong-Ming¹,Balkovec James M.¹,Pinto Shirly¹,Nargund Ravi P.¹,DeVita Robert J.¹

Affiliation:

1. Early Development and Discovery Sciences, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml5003426

Reference34 articles.

1. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

2. Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

3. Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

4. Cholesteryl esters and ACAT

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