Deducing the functional characteristics of the human selenoprotein SELK from the structural properties of its intrinsically disordered C-terminal domain

Author:

Polo Andrea12345,Colonna Giovanni12345,Guariniello Stefano67894,Ciliberto Gennaro101145,Costantini Susan121145

Affiliation:

1. Servizio di Informatica Medica

2. Azienda Ospedaliera Universitaria

3. Seconda Università di Napoli

4. Napoli

5. Italy

6. Dottorato in Biologia Computazionale

7. Dipartimento di Biochimica

8. Biofisica e Patologia generale

9. Seconda Università degli Studi di Napoli

10. Direttore Scientifico

11. IRCCS - Istituto Nazionale Tumori “Fondazione G. Pascale”

12. CROM

Abstract

The results evidence that during MD simulation SELK presents a distribution of equilibrium conformers which continuously inter-change their conformations.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Reference70 articles.

1. Intrinsically unstructured proteins and their functions

2. Function and structure of inherently disordered proteins

3. Intrinsically disordered protein

4. Intrinsic Protein Disorder, Amino Acid Composition, and Histone Terminal Domains

5. S. Costantini , M.Miele and G.Colonna, “Intrinsically Unordered Proteins: structural properties, prediction and relevance”, in Protein Folding, ed. Eric C. Walters, Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions, Nova Science Publishers, Inc., Hauppauge NY – USA, ch. 6, 2010, ISBN: 978-1-61761-259-6

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