Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring

Author:

Moi Davide12,Citarella Andrea12,Bonanni Davide1,Pinzi Luca1,Passarella Daniele2ORCID,Silvani Alessandra2ORCID,Giannini Clelia2ORCID,Rastelli Giulio1ORCID

Affiliation:

1. Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena 41125, Italy

2. Department of Chemistry, University of Milan, Via Golgi 19, Milano 20133, Italy

Abstract

Potent and selective inhibitors of HDAC6 have been designed, synthesized and tested. An unexpected opening of the quinazoline ring led to both aminotriazoloquinazoline and aminotriazole compounds with potent activity and isoform selectivity.

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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