Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines-Reference-Cited by-同舟云学术

Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines

Published:2017 Issue:17 Volume:15 Page:3717-3727
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bencze László Csaba¹²³⁴⁵,Filip Alina¹²³⁴⁵,Bánóczi Gergely⁶⁷⁸⁹,Toşa Monica Ioana¹²³⁴⁵,Irimie Florin Dan¹²³⁴⁵,Gellért Ákos¹⁰¹¹¹²¹³⁹,Poppe László¹²³⁴⁵^ORCID,Paizs Csaba¹²³⁴⁵^ORCID

Affiliation:

1. Biocatalysis and Biotransformation Research Centre

2. Faculty of Chemistry and Chemical Engineering

3. Babeş-Bolyai University of Cluj-Napoca

4. RO-400028 Cluj-Napoca

5. Romania

6. Department of Organic Chemistry and Technology

7. Budapest University of Technology and Economics

8. H-1111 Budapest

9. Hungary

10. Agricultural Institute

11. Centre of Agricultural Research

12. Hungarian Academy of Sciences

13. H-2462 Martonvásár

Abstract

The substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) towards the l-enantiomers of racemic styrylalanines rac-1a–d were extended by reshaping the aromatic binding pocket of the active site of PcPAL by point mutations of F137.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00562H

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