Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

Published:2010-02-19 Issue:5968 Volume:327 Page:1010-1013
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Srinivas Nityakalyani¹,Jetter Peter¹,Ueberbacher Bernhard J.¹,Werneburg Martina¹,Zerbe Katja¹,Steinmann Jessica¹,Van der Meijden Benjamin¹,Bernardini Francesca²,Lederer Alexander²,Dias Ricardo L. A.²,Misson Pauline E.²,Henze Heiko²,Zumbrunn Jürg²,Gombert Frank O.²,Obrecht Daniel²,Hunziker Peter³,Schauer Stefan³,Ziegler Urs⁴,Käch Andres⁴,Eberl Leo⁵,Riedel Kathrin⁵,DeMarco Steven J.²,Robinson John A.¹

Affiliation:

1. Chemistry Department, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

2. Polyphor AG, Hegenheimermattweg 125, 4123 Allschwil, Switzerland.

3. Functional Genomics Center Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

4. Center for Microscopy and Image Analysis, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

5. Department of Microbiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich.

Abstract

Killing Pseudomonas Gram-negative Pseudomonas bacteria are opportunistic pathogens, and drug-resistant strains present a serious health problem. Srinivas et al. (p. 1010 ) synthesized a family of peptidomimetic antibiotics that is active only against Pseudomonas . These antibiotics do not lyse the cell membrane, but instead target an essential outer membrane protein, LptD, which plays a role in the assembly of lipopolysaccharide in the outer cell membrane. Activity in a mouse infection model suggests that the antibiotics might have therapeutic potential. In addition, LptD is widely distributed in gram-negative bacteria and so its validation as a target has the potential to drive development of antibiotics with a broader spectrum of activity against gram-negative pathogens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Properties and structure–activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I

2. Macrocyclic Hairpin Mimetics of the Cationic Antimicrobial Peptide Protegrin I: A New Family of Broad-Spectrum Antibiotics

3. Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

4. Combinatorial Biomimetic Chemistry: Parallel Synthesis of a Small Library ofβ-Hairpin Mimetics Based on Loop III from Human Platelet-Derived Growth Factor B

5. The design, structures and therapeutic potential of protein epitope mimetics

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