Tunable gold nanorod/NAO conjugates for selective drug delivery in mitochondria-targeted cancer therapy

Author:

González-Rubio Sergio12,Salgado Cástor3,Manzaneda-González Vanesa1,Muñoz-Úbeda Mónica12,Ahijado-Guzmán Rubén1,Natale Paolo12ORCID,Almendro-Vedia Víctor G.12,Junquera Elena1ORCID,Barcina José Osío3ORCID,Ferrer Irene245,Guerrero-Martínez Andrés1ORCID,Paz-Ares Luis2456,López-Montero Iván127ORCID

Affiliation:

1. Departamento Química Física, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain

2. Instituto de Investigación Hospital Doce de Octubre (imas12), Avenida de Córdoba s/n, 28041 Madrid, Spain

3. Departamento Química Orgánica, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain

4. Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

5. Ciberonc, Madrid, Spain

6. Departamento de Medicina, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain

7. Instituto Pluridisciplinar, Ps. Juan XXIII 1, 28040 Madrid, Spain

Abstract

Nano-conjugates composed of gold nanorods and nonyl acridine orange (NAO) derivatives were built as a novel approach for mitochondria targeted-cancer therapy.

Funder

H2020 European Research Council

Comunidad de Madrid

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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