Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study

Author:

Alagia Adele12342ORCID,Jorge Andreia F.56789ORCID,Aviñó Anna12342ORCID,Cova Tânia F. G. G.56789ORCID,Crehuet Ramon123ORCID,Grijalvo Santiago12342ORCID,Pais Alberto A. C. C.56789ORCID,Eritja Ramon12342ORCID

Affiliation:

1. Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

2. E-08034 Barcelona

3. Spain

4. Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

5. CQC

6. Department of Chemistry

7. University of Coimbra

8. 3004-535 Coimbra

9. Portugal

Abstract

A direct connection between the PAZ/3′-overhang binding affinity and the siRNA potency and specificity is defined through complementary experimental and computational results.

Funder

Fundação para a Ciência e a Tecnologia

Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina

Departament d’Innovació, Universitats i Empresa, Generalitat de Catalunya

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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