Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones via cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides-Reference-Cited by-同舟云学术

Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones via cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides

Published:2019 Issue:45 Volume:17 Page:9708-9711
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jin Qiaomei¹²³⁴⁵^ORCID,Zhang Dongjian¹²³⁴⁵,Zhang Jian¹²³⁴⁵^ORCID

Affiliation:

1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine

2. Nanjing University of Chinese Medicine

3. Nanjing 210028

4. China

5. Laboratories of Translational Medicine

Abstract

A facile and efficient cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides has been achieved for rapid access to 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-one derivatives (up to 95% yield).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB02260K

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