Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
Author:
Affiliation:
1. Department of Biochemistry
2. University of Washington
3. Seattle
4. USA
5. Department of Medicine
6. Division of Allergy & Infectious Disease
7. Center for Emerging & Re-emerging Infectious Disease (CERID)
8. PATH
9. San Francisco
Abstract
Potent T. brucei methionyl-tRNA synthetase inhibitors built on two novel short and rigid linker systems.
Funder
National Institute of General Medical Sciences
National Institute of Allergy and Infectious Diseases
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00057D
Reference27 articles.
1. Neglected tropical diseases , https://www.who.int/neglected_diseases/diseases/en/ , (accessed Jan 2020 )
2. Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
3. Human African trypanosomiasis
4. Chemotherapy of trypanosomiases and leishmaniasis
5. Trypanocidal drugs: mechanisms, resistance and new targets
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