Trypanocidal drugs: mechanisms, resistance and new targets

Author:

Wilkinson Shane R.,Kelly John M.

Abstract

The protozoan parasitesTrypanosoma bruceiandTrypanosoma cruziare the causative agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating infections that exert a considerable health burden on some of the poorest people on the planet. Treatment of trypanosome infections is dependent on a small number of drugs that have limited efficacy and can cause severe side effects. Here, we review the properties of these drugs and describe new findings on their modes of action and the mechanisms by which resistance can arise. We further outline how a greater understanding of parasite biology is being exploited in the search for novel chemotherapeutic agents. This effort is being facilitated by new research networks that involve academic and biotechnology/pharmaceutical organisations, supported by public–private partnerships, and are bringing a new dynamism and purpose to the search for trypanocidal agents.

Publisher

Cambridge University Press (CUP)

Subject

Molecular Biology,Molecular Medicine

Reference262 articles.

1. http://www.gatesfoundation.org/Pages/home.aspx

2. http://www.dndi.org/

3. http://tritrypdb.org/tritrypdb/ Not-for-profit organisations involved in helping combat trypanosomal infections include Drugs for Neglected Diseases Initiative, Bill & Melinda Gates Foundation and the Wellcome Trust:

4. http://www.genedb.org/genedb/tcruzi/

5. Eflornithine for the treatment of human African trypanosomiasis;Burri;Parasitology Research,2003

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