The active role of Ca2+ ions in Aβ-mediated membrane damage
Author:
Affiliation:
1. Istituto di Biostrutture e Bioimmagini
2. Consiglio Nazionale delle Ricerche
3. Sede Secondaria di Catania
4. Catania
5. Italy
6. Università degli Studi di Catania
7. Dipartimento di Scienze Chimiche
8. 95125 Catania
Abstract
Calcium ions inhibits Aβ induced membrane poration by small-sized oligomers but significantly foster fiber-dependent membrane disruption.
Funder
Ministero dell'Istruzione, dell'Università e della Ricerca
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC01132J
Reference19 articles.
1. The molecular pathology of Alzheimer's disease
2. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
3. Alzheimer's disease and Aβ toxicity: from top to bottom
4. Aβ ion channels. Prospects for treating Alzheimer's disease with Aβ channel blockers
5. Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
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