A two-pronged strategy to alleviate tumor hypoxia and potentiate photodynamic therapy by mild hyperthermia-Reference-Cited by-同舟云学术

A two-pronged strategy to alleviate tumor hypoxia and potentiate photodynamic therapy by mild hyperthermia

Published:2023 Issue:1 Volume:11 Page:108-118
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhang Zhijie¹,Wang Zibing¹,Xiong Yuxuan¹,Wang Chong¹,Deng Qingyuan¹,Yang Tian¹,Xu Qingqing¹,Yong Zhengtao¹,Yang Xiangliang¹²³⁴⁵^ORCID,Li Zifu¹³⁴⁵⁶^ORCID

Affiliation:

1. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

2. GBA Research Innovation Institute for Nanotechnology, Guangdong, 510530, P. R. China

3. Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

4. Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

5. Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

6. Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

Abstract

Mild hyperthermia boosts the catalase activity of HMPB NPs for internal O2 generation and normalized tumor vasculature for external O2 supply, cooperatively disrupting tumor hypoxia and augmenting Ce6-mediated PDT against breast cancers.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Huazhong University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01691E

Reference74 articles.

1. Clinical development and potential of photothermal and photodynamic therapies for cancer