Non-covalent PEGylation of proteins mediated by site-specific <i>in situ</i> polymerization induced co-assembly-Reference-Cited by-同舟云学术

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Non-covalent PEGylation of proteins mediated by site-specific in situ polymerization induced co-assembly

Published:2024 Issue:19 Volume:15 Page:1942-1946
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Jiao Fei¹,Su Qinzhi¹,Liu Xinyu¹²^ORCID

Affiliation:

1. Central Laboratory, NMPA Key Laboratory for Dental Materials, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, 100081, China

2. Institute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China

Abstract

A novel strategy of non-covalent PEGylation termed site-specific in situ polymerization induced co-assembly (SI-PICA) is presented. This approach maintains protein bioactivity while improving pharmacokinetic properties.

Funder

Beijing Nova Program

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/PY/D4PY00260A

Reference40 articles.

1. Protein therapeutics: a summary and pharmacological classification

2. Top companies and drugs by sales in 2021

3. Immunogenicity of protein therapeutics

4. Effect of pegylation on pharmaceuticals

5. Half-life extended biotherapeutics

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