Real-time imaging of nanobubble ultrasound contrast agent flow, extravasation, and diffusion through an extracellular matrix using a microfluidic model-Reference-Cited by-同舟云学术

Real-time imaging of nanobubble ultrasound contrast agent flow, extravasation, and diffusion through an extracellular matrix using a microfluidic model

Published:2023 Issue:15 Volume:23 Page:3453-3466
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Cooley Michaela B.¹^ORCID,Wulftange William J.¹^ORCID,Wegierak Dana¹^ORCID,Goreke Utku²,Abenojar Eric C.³^ORCID,Gurkan Umut A.¹²^ORCID,Exner Agata A.¹³^ORCID

Affiliation:

1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA

2. Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA

3. Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, USA

Abstract

The ultrasound-capable microfluidic chip is a tunable, real-time method for isolating complexin vivoparameters to study nanoparticle extravasation through a heterogeneous ECM.

Funder

National Institute of Biomedical Imaging and Bioengineering

National Cancer Institute

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

National Science Foundation

National Center for Advancing Translational Sciences

Harrington Discovery Institute, University Hospitals

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering