A scalable filtration method for high throughput screening based on cell deformability

Author:

Gill Navjot Kaur1234ORCID,Ly Chau5234,Nyberg Kendra D.1234ORCID,Lee Linus1234,Qi Dongping1234ORCID,Tofig Bobby67234,Reis-Sobreiro Mariana8934ORCID,Dorigo Oliver101112134,Rao JianYu14234,Wiedemeyer Ruprecht15934,Karlan Beth15934,Lawrenson Kate15934,Freeman Michael R.8934,Damoiseaux Robert67234,Rowat Amy C.1234ORCID

Affiliation:

1. Department of Integrative Biology and Physiology

2. University of California Los Angeles

3. Los Angeles

4. USA

5. Department of Bioengineering

6. Molecular Screening Shared Resource

7. California NanoSystems Institute

8. Department of Surgery and Biomedical Sciences

9. Cedars-Sinai Medical Center

10. Department of Obstetrics and Gynecology

11. Stanford Cancer institute

12. Stanford University

13. Stanford

14. Department of Pathology and Laboratory Medicine

15. Samuel Oschin Comprehensive Cancer Institute

Abstract

We demonstrate a scalable, high throughput method to screen cells based on their ability to deform through micron-scale gaps.

Funder

National Science Foundation

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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