Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system

Author:

Jiang Yihui12345,Wang Chunlan12345,Ma Nana678910,Chen Jie678910,Liu Chuanfei6789,Wang Fang12345,Xu Jiakun12345ORCID,Cong Zhiqi678910ORCID

Affiliation:

1. Key Lab of Sustainable Development of Polar Fisheries

2. Ministry of Agriculture and Rural Affairs

3. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences

4. Lab for Marine Drugs and Byproducts of Pilot National Lab for Marine Science and Technology

5. Qingdao 266071

6. CAS Key Laboratory of Biofuels and Shandong Provincial Key Laboratory of Synthetic Biology

7. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences

8. Qingdao

9. China

10. University of Chinese Academy of Sciences

Abstract

Highly regioselective O-demethylation of aromatic ethers related to the bioconversion of lignin was achieved by the H2O2-dependent engineered P450BM3 enzymes with assistance of a dual-functional small molecule (DFSM) for the first time.

Funder

National Natural Science Foundation of China

Ministry of Agriculture and Rural Affairs of the People's Republic of China

Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

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