Protecting group free radical C–H trifluoromethylation of peptides
Author:
Affiliation:
1. Chemistry Capabilities and Screening
2. Merck Sharp & Dohme Corp.
3. Kenilworth
4. USA
5. Kenilworth Discovery Chemistry
6. Analytical Research & Development
7. Rahway
8. West Point Discovery Chemistry
9. Discovery Chemistry Modalities
Abstract
Two radical-based approaches enable the efficient trifluoromethylation of aromatic sidechains in fully unprotected peptides under mild, biocompatible conditions.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00368H
Reference49 articles.
1. The Future of Peptide-based Drugs
2. Peptide therapeutics: current status and future directions
3. Residue-Specific Peptide Modification: A Chemist’s Guide
4. Choosing an effective protein bioconjugation strategy
5. Advances in Chemical Protein Modification
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