Protecting group free radical C–H trifluoromethylation of peptides-Reference-Cited by-同舟云学术

Protecting group free radical C–H trifluoromethylation of peptides

Published:2018 Issue:17 Volume:9 Page:4168-4175
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ichiishi Naoko¹²³⁴,Caldwell John P.⁵²³⁴,Lin Melissa⁶²⁷⁴,Zhong Wendy⁶²⁷⁴,Zhu Xiaohong⁵²³⁴,Streckfuss Eric⁸²⁴,Kim Hai-Young⁶²⁷⁴,Parish Craig A.⁹²³⁴,Krska Shane W.¹²³⁴^ORCID

Affiliation:

1. Chemistry Capabilities and Screening

2. Merck Sharp & Dohme Corp.

3. Kenilworth

4. USA

5. Kenilworth Discovery Chemistry

6. Analytical Research & Development

7. Rahway

8. West Point Discovery Chemistry

9. Discovery Chemistry Modalities

Abstract

Two radical-based approaches enable the efficient trifluoromethylation of aromatic sidechains in fully unprotected peptides under mild, biocompatible conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00368H

Reference49 articles.

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2. Peptide therapeutics: current status and future directions

3. Residue-Specific Peptide Modification: A Chemist’s Guide

4. Choosing an effective protein bioconjugation strategy

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