Converting disulfide bridges in native peptides to stable methylene thioacetals
Author:
Affiliation:
1. Laboratory of Asymmetric Catalysis and Synthesis
2. Institute of Chemical Sciences and Engineering
3. Ecole Polytechnique Fédérale de Lausanne
4. EPFL SB ISIC LCSA
5. CH-1015 Lausanne
Abstract
A mild and simple protocol converts the labile disulfide bond of unprotected native peptides into highly stable methylene thioacetals, annihilating reductive lability and increasing stability.
Funder
Swiss National Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC02285E
Reference67 articles.
1. Therapeutic peptides: technological advances driving peptides into development
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