Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases

Author:

Sebti Yasmine1ORCID,Si-Mohamed Salim23ORCID,Aid Rachida14ORCID,Geinguenaud Frederic1ORCID,Chalal Mohand5ORCID,Lalatonne Yoann16ORCID,Chaubet Frederic1ORCID,Ou Phalla17ORCID,Motte Laurence1ORCID

Affiliation:

1. Université Sorbonne Paris Nord and Université Paris Cité, INSERM, LVTS, F-75018 Paris, France

2. Department of Cardiovascular and Thoracic Radiology, Louis Pradel Hospital, Hospices Civils de Lyon, 59 Boulevard Pinel, 69500 Bron, France

3. CREATIS, UMR 5220, Univ Lyon, INSA Lyon, University Claude Bernard Lyon 1, Lyon, France

4. Université de Paris, FRIM, UMS 034, INSERM, F-75018, Paris, France

5. Université Sorbonne Paris Nord, CNRS, CSPBAT, F-93017 Bobigny, France

6. Service de Biophysique et Médecine Nucléaire, Hôpital Avicenne AP-HP, F-93009 Bobigny, France

7. Département de Radiologie, Hôpital Bichat, Université de Paris, Assistance Publique Hôpitaux de Paris, Paris, France

Abstract

HfO2NPs surface functionalized with fucoidan show specific targeting of aggregated platelets and appear as a new candidate for X-ray imaging for the molecular-scale diagnosis of atherothrombosis.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Chemistry (miscellaneous)

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